Bioinformatics faculty build diverse research programs aimed at advancing state-of-the-art molecular and cellular profiling technologies for applications to cancer research. Our work combines a wide range of molecular biology, immunology, cellular biology and metabolism techniques, with state-of-the-art quantitative methods to explore large data sets. Technologies span from high-throughput genetic sequencing, transcriptional profiling, epigenetics, and single-cell and spatial multi-omics. Bioinformatics methodology development is fueled by solving research problems in basic and translational research, simultaneously advancing the fields of bioinformatics and computational oncology. These techniques go beyond theory to translation for cancer research, including as examples advanced technologies for blood based biomarkers and characterization of the tumor immune system during immunotherapy response.